Pharmacokinetic (PK) parameters such as AUC last and C max were predicted with the established in vitro–in vivo correlation (IVIVC) models. Percent in vivo absorbed was calculated by using numerical deconvolution (NDC) and non-compartmental analysis (NCA) methods. A suitable polynomial mathematical model was used to establish a correlation between time and %Ct n. In order to minimize the run-to-run variability during in vitro skin permeation studies, release normalized cumulative percent (%Ct n) was calculated. ![]() The present study aims to develop the correlation between in vitro and in vivo skin permeation of lidocaine in its transdermal patch.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |